Name:

Dr. Bernard Perbal

Centre:

Université Paris 7 Denis-Diderot

2 Place Jussieu

Paris, France

Tel:+33 1 44275704   Fax:+33 1 30641865

e-mail: perbal@ccr.jussieu.fr

Professor of Molecular Pathology and Molecular Biology. Head of the Laboratoire d’Oncologie Virale et Moléculaire since 1982, at the Curie Institute, INSERM and University Paris 7. Associated Professor at Wuhuan University (China) since 1995. Recipient of several awards from the french National Academy of Science, INSERM, and Ligue Nationale contre le Cancer.  Discoverer of the NOV gene in 1991.

Personnel involved in studies related to PROTHET's:

Nathalie PLANQUE Assistant Professor of the Université Paris 7 since 2002. Now studying the molecular processes responsible for the generation and processing of the different NOV isoforms in normal and tumor cells.

Anne-Marie BLEAU Canadian Post Doc. Graduated in pharmacology at the university of Montreal in 2002. Recipient of several honorific awards including Prix d’excellence Glaxo.

Chang Long LI Assistant Professor of the West China University of Medical Sciences. Worked  in the department of molecular Biology and Biochemistry. Is presently studying the regulation of nov expression and role of nov in calcium signaling.

Myriam GROSPIERRE Technical agent university Paris 7.

Damien MARQUES American student preparing a PhD in the laboratory.

Sophie VIBET Pre Doc. Will be assigned to the construction of recombinant clones to be transfected in the ESFT cells.

Recent Publications relevant to the project:

Li CL, Martinez V, He B, Lombet A, Perbal B. (2002) A role for CCN3 (NOV) in calcium signalling. Mol Pathol. 55(4):250-61.

Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K. (2002) The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. J Biol Chem. 277(33):29399-405.

Manara MC, Perbal B, Benini S, Strammiello R, Cerisano V, Perdichizzi S, Serra M, Astolfi A, Bertoni F, Alami J, Yeger H, Picci P, Scotlandi K. (2002) The expression of ccn3(nov) gene in musculoskeletal tumors. Am J Pathol 160(3):849-59.

Perbal B, Martinerie C, Sainson R, Werner M, He B, Roizman B. (1999) The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. Proc Natl Acad Sci U S A. 96(3):869-74.

Chevalier G, Yeger H, Martinerie C, Laurent M, Alami J, Schofield PN, Perbal B. (1998) novH: differential expression in developing kidney and Wilm's tumors. Am J Pathol 152(6):1563-75